This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations, including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant RegistryThe original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases.The book also now includes a fully searchable CD with PDFs of the entire content. Content: Chapter 1 A History of Allogeneic Hematopoietic Cell Transplantation (pages 1–7): E. Donnall ThomasChapter 2 The History of Autologous Hematopoietic Cell Transplantation (pages 8–14): James O. ArmitageChapter 3 Uses and Growth of Hematopoietic Cell Transplantation (pages 15–21): Mary M. HorowitzChapter 4 Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Embryonic Stem Cells (pages 23–35): Laurence Daheron and David T. ScaddenChapter 5 Biology of Hematopoietic Stem and Progenitor Cells (pages 36–63): Susan Prohaska and Irving WeissmanChapter 6 Molecular Biology of Stem Cell Renewal (pages 64–71): Peter M. LansdorpChapter 7 Cellular Biology of Hematopoiesis (pages 72–87): Catherine M. Flynn and Catherine M. VerfaillieChapter 8 Expansion of Hematopoietic Stem Cells (pages 88–101): Colleen Delaney and Irwin BernsteinChapter 9 Mesenchymal Stromal Cells and Hematopoietic Cell Transplantation (pages 102–115): Edwin M. HorwitzChapter 10 Genetic Manipulation of Hematopoietic Stem Cells (pages 116–128): Grant D. Trobridge and Hans?Peter KiemChapter 11 Overview of Hematopoietic Cell Transplantation Immunology (pages 129–144): Paul J. MartinChapter 12 Histocompatibility (pages 145–162): Eric Mickelson and Effie W. PetersdorfChapter 13 Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation (pages 163–175): Michael R. Verneris and Jeffrey S. MillerChapter 14 Murine Models of Graft?versus?Host Disease and Graft?versus?Tumor Effect (pages 176–187): Robert Korngold and Thea M. FriedmanChapter 15 Mechanisms of Tolerance (pages 188–207): Megan SykesChapter 16 The Pathophysiology of Graft?Versus?Host Disease (pages 208–221): James L. M. Ferrara and Joseph H. AntinChapter 17 Immune Reconstitution Following Hematopoietic Cell Transplantation (pages 222–231): Robertson Parkman and Kenneth I. WeinbergChapter 18 The Human Graft?versus?Tumor Response – and How to Exploit It (pages 232–247): Edus H. WarrenChapter 19 Dendritic Cells in Hematopoietic Cell Transplantation (pages 248–263): Miriam Merad, Matthew P. Collin and Edgar G. EnglemanChapter 20 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases (pages 264–285): Judith A. ShizuruChapter 21 Pharmacologic Basis for High?dose Chemotherapy (pages 287–315): James H. Doroshow and Timothy W. SynoldChapter 22 High?dose Preparatory Regimens (pages 316–332): William I. BensingerChapter 23 Radiotherapeutic Principles of Hematopoietic Cell Transplantation (pages 333–350): Jeffrey Y. C. Wong and Timothy SchultheissChapter 24 Radioimmunotherapy and Hematopoietic Cell Transplantation (pages 351–364): Damian J. Green and Oliver W. PressChapter 25 Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation (pages 365–375): Paul J. MartinChapter 26 The Detection and Significance of Minimal Residual Disease (pages 376–389): Jerald P. Radich and Marilyn L. SlovakChapter 27 Pathology of Hematopoietic Cell Transplantation (pages 390–405): Howard M. Shulman, Robert C. Hackman and George E. SaleChapter 28 Biostatistical Methods in Hematopoietic Cell Transplantation (pages 406–427): Joyce C. Niland and Paul FrankelChapter 29 Outcomes Research in Hematopoietic Cell Transplantation (pages 428–441): Stephanie J. LeeChapter 30 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation (pages 443–460): Karl G. Blume and Robert A. KranceChapter 31 Nursing Role in Hematopoietic Cell Transplantation (pages 461–477): Rosemary C. Ford and Mihkaila M. WicklineChapter 32 Ethical Issues in Hematopoietic Cell Transplantation (pages 478–487): David S. SnyderChapter 33 Psychosocial Issues in Hematopoietic Cell Transplantation (pages 488–501): Richard P. McQuellon and Michael AndrykowskiChapter 34 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients (pages 502–514): Karen L. Syrjala and Samantha Burns ArtherholtChapter 35 Sexuality Following Hematopoietic Cell Transplantation: An Important Health?related Quality of Life Issue (pages 515–525): D. Kathryn TierneyChapter 36 Hematopoietic Cell Transplantation: The Patient`s Perspective (pages 526–532): Susan K. StewartChapter 37 Hematopoietic Cell Procurement, Processing, and Transplantation: Standards, Accreditation, and Regulation (pages 533–543): Phyllis I. Warkentin and Elizabeth J. ShpallChapter 38 Bone Marrow and Peripheral Blood Cell Donors and Donor Registries (pages 544–558): Dennis L. Confer, John P. Miller and Jeffrey W. ChellChapter 39 Cord Blood Hematopoietic Cell Transplantation (pages 559–576): Hal E. Broxmeyer and Franklin O. SmithChapter 40 In Utero Transplantation (pages 577–589): Alan W. Flake and Esmail D. ZanjaniChapter 41 Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Cellular Therapy (pages 590–604): Thomas C. Shea and John F. DiPersioChapter 42 Removal of Tumor Cells from the Hematopoietic Graft (pages 605–617): John G. GribbenChapter 43 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation (pages 618–630): Norbert SchmitzChapter 44 Cryopreservation of Hematopoietic Cells (pages 631–644): Scott D. RowleyChapter 45 Use of Recombinant Growth Factors after Hematopoietic Cell Transplantation (pages 645–656): Jurgen Finke and Roland MertelsmannChapter 46 Hematopoietic Cell Transplantation from Human Leukocyte Antigen Partially Matched Related Donors (pages 657–674): Claudio Anasetti, Franco Aversa and Andrea VelardiChapter 47 Hematopoietic Cell Transplantation from Unrelated Donors (pages 675–691): Effie W. PetersdorfChapter 48 Donor Selection for Hematopoietic Cell Transplantation (pages 692–703): Ann E. WoolfreyChapter 49 Hematopoietic Cell Transplantation for Aplastic Anemia (pages 705–726): George E. Georges and Rainer StorbChapter 50 Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria (pages 727–733): Robert P. WitherspoonChapter 51 Allogeneic and Autologous Transplantation for Chronic Myeloid Leukemia (pages 734–750): Jerald P. Radich and Ravi BhatiaChapter 52 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia (pages 751–760): Charlotte M. Niemeyer and Franco LocatelliChapter 53 Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia (pages 761–774): Frederick R. AppelbaumChapter 54 Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia (pages 775–790): Julie?An M. Talano, James T. Casper and David A. MargolisChapter 55 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults (pages 791–805): Stephen J. FormanChapter 56 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children (pages 806–826): Parinda A. Mehta and Stella M. DaviesChapter 57 Hematopoietic Cell Transplantation for Myelodysplastic Syndrome and Myeloproliferative Disorders (pages 827–844): H. Joachim DeegChapter 58 Hematopoietic Cell Transplantation for Multiple Myeloma (pages 845–859): Muzaffar H. Qazilbash and Sergio A. GiraltChapter 59 Hematopoietic Cell Transplantation for Hodgkin`s Disease (pages 860–877): Philip J. Bierman and Auayporn NademaneeChapter 60 Non?Hodgkin`s Lymphoma (pages 878–896): Laura J. Johnston and Sandra J. HorningChapter 61 Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia (pages 897–913): David B. MiklosChapter 62 Autologous Hematopoietic Cell Transplantation for Systemic Light Chain (AL?) Amyloidosis (pages 914–930): Raymond L. Comenzo and Morie A. GertzChapter 63 Hematopoietic Cell Transplantation for Breast Cancer (pages 931–947): Yago Nieto and Elizabeth J. ShpallChapter 64 Hematopoietic Cell Transplantation in Germ Cell Tumors (pages 948–957): Christie J. Moore, Brandon Hayes?Lattin and Craig R. NicholsChapter 65 Hematopoietic Cell Transplantation for Renal Cell and other Solid Tumors (pages 958–959): Richard W. Childs and Ramaprasad SrinivasanChapter 66 Hematopoietic Cell Transplantation for Neuroblastoma (pages 970–984): Jason Law and Katherine K. MatthayChapter 67 Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors (pages 985–1000): David M. Loeb and Allen R. ChenChapter 68 Hematopoietic Cell Transplantation for Patients with Human Immunodeficiency Virus Infection (pages 1001–1013): John A. Zaia, Amrita Krishnan and John J. RossiChapter 69 Hematopoietic Cell Transplantation for Autoimmune Diseases (pages 1014–1029): Richard A. NashChapter 70 Hematopoietic Cell Transplantation for Rare Hematologic Malignancies (pages 1030–1042): Vinod Pullarkat and Stephen J. FormanChapter 71 Reduced?intensity Conditioning Followed by Hematopoietic Cell Transplantation for Hematologic Malignancies (pages 1043–1058): Brenda M. Sandmaier and Rainer StorbChapter 72 Management of Relapse after Hematopoietic Cell Transplantation (pages 1059–1075): Ginna G. Laport and Robert S. NegrinChapter 73 Hematopoietic Cell Transplantation for Thalassemia (pages 1077–1089): Guido Lucarelli and Javid GazievChapter 74 Hematopoietic Cell Transplantation for Sickle Cell Disease (pages 1090–1104): Mark C. WaltersChapter 75 Hematopoietic Cell Transplantation for Immunodeficiency Diseases (pages 1105–1124): Trudy N. Small, Wilhelm Friedrich and Richard J. O`ReillyChapter 76 Hematopoietic Cell Transplantation for Osteopetrosis (pages 1125–1135): Peter F. CocciaChapter 77 Hematopoietic Cell Transplantation for Storage Diseases (pages 1136–1162): Charles PetersChapter 78 Hematopoietic Cell Transplantation for Macrophage and Granulocyte Disorders (pages 1163–1177): Rajni AgarwalChapter 79 Hematopoietic Cell Transplantation for Fanconi`s Anemia (pages 1178–1199): John E. Wagner, Margaret L. Macmillan and Arleen D. AuerbachChapter 80 Mechanisms and Treatment of Graft Failure (pages 1201–1218): Robert Lowsky and Hans MessnerChapter 81 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation (pages 1219–1225): Margaret R. O`DonnellChapter 82 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation (pages 1226–1243): Jeffrey McCulloughChapter 83 Vascular Access and Complications (pages 1244–1256): I. Benjamin PazChapter 84 Pharmacologic Prevention of Acute Graft?Versus?Host Disease (pages 1257–1274): Nelson J. Chao and Keith M. SullivanChapter 85 T?Cell Depletion to Prevent Graft?versus?Host Disease (pages 1275–1286): Robert J. SoifferChapter 86 Manifestations and Treatment of Acute Graft?Versus?Host Disease (pages 1287–1303): Corey Cutler and Joseph H. AntinChapter 87 Chronic Graft?versus?Host Disease: Clinical Manifestations and Therapy (pages 1304–1324): Steven Z. Pavletic and Georgia B. VogelsangChapter 88 Bacterial Infections (pages 1325–1345): Helen L. Leather and John R. WingardChapter 89 Fungal Infections after Hematopoietic Cell Transplantation (pages 1346–1366): Janice (Wes) M. Y. BrownChapter 90 Cytomegalovirus Infection (pages 1367–1381): John A. ZaiaChapter 91 Herpes Simplex Virus Infections (pages 1382–1387): James I. ItoChapter 92 Varicella?zoster Virus Infections (pages 1388–1409): Dora Y. Ho and Ann M. ArvinChapter 93 Epstein–Barr Virus Infection (pages 1410–1418): Wen?Son Hsieh and Richard F. AmbinderChapter 94 Adenoviruses, Respiratory Viruses, HHV?6, HHV?7, HHV?8, Papovaviruses and Other Viruses After Hematopoietic Cell Transplantation (pages 1419–1433): Michael BoeckhChapter 95 Gastrointestinal and Hepatic Complications (pages 1434–1455): Simone I. Strasser and George B. McDonaldChapter 96 Lung Injury Following Hematopoietic Cell Transplantation (pages 1456–1472): Kenneth R. Cooke and Gregory A. YanikChapter 97 Kidney and Bladder Complications of Hematopoietic Cell Transplantation (pages 1473–1486): Sangeeta HingoraniChapter 98 Endocrine Complications Following Hematopoietic Cell Transplantation (pages 1487–1522): Fouad R. KandeelChapter 99 Common Potential Drug Interactions Following Hematopoietic Cell Transplantation (pages 1523–1538): Anne Poon and Lowan LyChapter 100 Critical Care of the Hematopoietic Cell Transplant Recipient (pages 1539–1550): Gundeep S. Dhillon and Norman W. RizkChapter 101 Nutrition Support of the Hematopoietic Cell Transplant Recipient (pages 1551–1569): Polly Lenssen and Saundra AkerChapter 102 Pain Management (pages 1570–1588): Noelle V. Frey and Jonathan R. GavrinChapter 103 Oral Complications of Hematopoietic Cell Transplantation (pages 1589–1607): Mark M. Schubert and Douglas E. PetersonChapter 104 Growth and Development after Hematopoietic Cell Transplantation (pages 1608–1619): Jean E. SandersChapter 105 Delayed Nonmalignant Complications after Hematopoietic Cell Transplantation (pages 1620–1637): Mary E. D. Flowers and H. Joachim DeegChapter 106 Secondary Malignancies after Hematopoietic Cell Transplantation (pages 1638–1652): Smita Bhatia and Ravi BhatiaChapter 107 Neurologic Complications of Hematopoietic Cell Transplantation (pages 1653–1663): Harry OpenshawChapter 108 Vaccination of Allogeneic and Autologous Hematopoietic Cell Recipients (pages 1664–1670): Trudy N. SmallChapter 109 Hematopoietic Cell Transplantation in the Future (pages 1671–1676): Ernest Beutler

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